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Jialiu Zeng, Ph.D.

Principal Investigator

Jialiu obtained her Ph.D. from Boston University where she developed novel biomaterials and nanoparticles and applied them to investigate the role of lysosomal and autophagy dysfunctions in metabolic diseases (type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)) and neurodegenerative diseases (Parkinson’s disease (PD)). In her postdoctoral trainings, she focused on understanding α-synuclein pathology in both familial and sporadic PD using human induced pluripotent stem cell (iPSC) derived neurons, relevant mouse models, and post-mortem human brain tissues. Jialiu’s research interest focuses on engineering new tools and developing nanomedicine to target IDP aggregation and autolysosomal dysfunctions as well as modulate insulin signaling, specifically in metabolic disorders and neurodegenerative diseases.

Education and Experiences
B.Eng. (Biomedical Engineering), National University of Singapore (NUS), Singapore (2010-2014)
Ph.D. (Biomedical Engineering), Boston University (BU), USA (2014-2020) 
Postdoctoral Associate (Neuroscience), Yale University, School of Medicine, USA (2020-2021)
Presidential Postdoctoral Fellow (Neuroscience), Nanyang Technological University (NTU), LKC Medicine, Singapore (2021-Present)

Honors and Awards
2023 (Mar)      1 of the 10 Young Scientists selected by the National Research Foundation as Singapore representatives,
                        72nd Lindau Nobel Laureate Meeting (Physiology or Medicine), Germany

2022 (Sep)      Silver Award - Tan Kah Kee Young Inventors National Competition (Open Category)
2022 (Mar)      Women in Engineering, Science, and Technology (WiEST) Development Grant, NTU, Singapore
2021–2024      Presidential Postdoctoral Fellowship (Independent Research Grant), LKC Medicine, NTU, Singapore 
2021 (July)      Best Oral Presentation, Postdoctoral Association Symposium, Yale University, USA
2020 (Dec)      Featured for Mentor-Graduate Student Spotlight, Journal of Life Sciences
2017 (Jan)       Travel Fellowship, Invitation to the Global Young Scientists Summit, Singapore
2016-2018       BUNano Cross-disciplinary Fellowship, Boston University, USA

2015-2016       Cross-disciplinary Training in Nanotechnology Fellowship,  Boston University, USA
2014-2015       Distinguished Biomedical Engineering Fellowship, Boston University, USA
2014 (May)      The Biomedical Engineering Society Award, NUS, Singapore (Top 3 of the Graduating Cohort)
2014 (May)      President’s Honor Roll (University Scholars Program), NUS, Singapore


Link to Publication List for Jialiu Zeng
 
Patents
1.  Lo CH, Zeng J, Perez-Aguilar JM, Baizabal-Aguirre VM. Peptide-based therapeutics with anti-inflammatory properties.
Singapore Provisional Patent Application No. 10202400831U.
2. Shirihai OS, Grinstaff MW, Zeng J. Acidic nanoparticles for restoration of autophagy. U.S. Patent  No. 10925975.
3. Tan JKS, Song SW, Goh AJY,
Lo CH, Zeng J. Palm sticker as a personal protection equipment and as a surface swab.
US Provisional Patent Application No. 63/176,444.

Grants
1. Young Investigator Research Grant, National Medical Research Council, Singapore (PI: Zeng)            
Project Title: Proteomic profiling of exosome molecular signatures in alpha-synuclein induced Parkinson’s disease
Timeline: 2022 – 2025 (In Progress)
2. Presidential Postdoctoral Fellowship, LKC School of Medicine, Nanyang Technological University, Singapore (PI: Zeng)   
Project Title: Role of lysosomal acidification in α-synuclein degradation and spreading in Parkinson’s disease
Timeline: 2021 – 2024 (Completed)

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