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Jialiu Zeng, Ph.D.

Team Leader

Jialiu obtained her Ph.D. from Boston University where she investigated the role of lysosomal acidity in autophagic flux and cellular function in metabolic diseases including Type II diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), as well as neurodegenerative diseases (Parkinson’s disease, PD) using novel synthesized nanoparticles. She moved on to do a postdoctoral training at Yale School of Medicine where she focused on studying alpha-synuclein pathology along the gut-brain axis in PD and investigating the role of glycosphingolipids in the pathogenesis of Gaucher-disease linked PD, using human induced pluripotent stem cell (iPSC) derived neuronal models and CRISPR-Cas9 technology. Jialiu’s research interest focuses on lysosomal dysfunction related disorders, specifically related to neurodegenerative and metabolic diseases.

Education and Experiences
B.Eng. (Biomedical Engineering), National University of Singapore, NUS, Singapore (2010-2014)
M.S. (Biomedical Engineering), Boston University, USA (2014-2017)
Ph.D. (Biomedical Engineering), Boston University, USA (2017-2020) 
Postdoc (Neurology & Neuroscience), Yale University, School of Medicine, USA (2020-2021)
Presidential Postdoctoral Fellow (Neuroscience), LKC School of Medicine, Nanyang Technological University (NTU), Singapore (2021-Present)

Honors and Awards
2023 (Mar)      Selected participant by National Research Foundation as Singapore representative,
                         72nd Lindau Nobel Laureate Meeting (Physiology and Medicine), Germany
2022-2025     Open Fund - Young Individual Research Grant, National Medical Research Council, Singapore
2022 (Sep)      Silver Award - Tan Kah Kee Young Inventors Competition (Open Category)
2022 (Mar)      Women in Engineering, Science, and Technology (WiEST) Development Grant, NTU, Singapore
2021–2023     NTU LKC School of Medicine Presidential Postdoctoral Fellowship
2021 (July)       Yale University Postdoc Association Symposium Best Oral Presentation 
2020 (Dec)      Featured for Mentor-Graduate Student Spotlight, Journal of Life Sciences
2017  (Jan)       Travel Fellowship, Invitation to the Global Young Scientists Summit, Singapore
2016-2018       BUNano Cross-disciplinary Fellowship, Boston University, USA

2015-2016       Cross-disciplinary Training in Nanotechnology Fellowship,  Boston University, USA
2014-2015       Distinguished Biomedical Engineering Fellowship, Boston University, USA
2014  (May)     The Biomedical Engineering Society Award, NUS, Singapore (Top 3 of the Graduating Cohort)
2014  (May)     President’s Honor Roll (University Scholars Program), NUS, Singapore


Link to Publication List for Jialiu Zeng
 
Patents
1.  Lo CH, Zeng J, Perez-Aguilar JM, Baizabal-Aguirre VM. Peptide-based therapeutics with anti-inflammatory properties. Singapore Provisional Patent Application No. 10202400831U.
2. Shirihai OS, Grinstaff MW, Zeng J. Acidic nanoparticles for restoration of autophagy. U.S. Patent  No. 10925975.
3. Tan JKS, Song SW, Goh AJY,
Lo CH, Zeng J. Palm sticker as a personal protection equipment and as a surface swab. US Provisional Patent Application No. 63/176,444.

Grants
1. Open Fund - Young Individual Research Grant, National Medical Research Council, Singapore (PI: Zeng)            
Project Title: Proteomic profiling of exosome molecular signatures in alpha-synuclein induced Parkinson’s disease
Timeline: 2022 – 2025 (In Progress)
2. LKC School of Medicine Presidential Postdoctoral Fellowship, Nanyang Technological University, Singapore (PI: Zeng)            
Project Title: Role of lysosomal acidification in α-synuclein degradation and spreading in Parkinson’s disease
Timeline: 2021 – 2023 (Completed)
3. Early-Career Researcher Pilot Grant, NISTH, NTU, Singapore (PI: Zeng)   
Project Title: Engineering of lysosome-targeted nanoparticles with enhanced brain penetration and neuroprotection 
Timeline: July 2023 - Dec 2023 (Completed)
4. NUS Innovation Challenge, National University of Singapore (Co-PI: Zeng)   
Project Title: Design of a novel hand-targeted PPE against fomite transmission of SARS-CoV-2 virus
Timeline: 2021 – 2022 (Completed)

5. BUNano Cross-disciplinary Fellowship, Boston University (PI: Zeng)            
Project Title: Biodegradable acidic nanoparticles for restoration of lysosomal pH and autophagic flux in Parkinson’s disease model and in vivo NAFLD mouse model
Timeline: 2016 – 2018 (Completed)
6. Cross-disciplinary Training in Nanotechnology Fellowship, Boston University (PI: Zeng)            
Project Title: Biodegradable acidic nanoparticles for restoration of lysosomal pH and autophagic flux in T2D and NAFLD cell-based models
Timeline: 2015 – 2016 (Completed)

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