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Chih Hung Lo, Ph.D.

Principal Investigator

Chih Hung obtained his Ph.D. from University of Minnesota where he investigated the molecular mechanisms of inflammation (TNF receptor signaling) and neurodegeneration (IDP aggregation). He also launched several drug discovery campaigns by combining fluorescent biosensor engineering, high-throughput screening, and medicinal chemistry. In his postdoctoral trainings, Chih Hung delved into neurobiology of aging to (1) use mouse genetics to study age-dependent neurodegeneration in Alzheimer's disease (AD) & (2) perform highly multiplexed immunofluorescence imaging on post-mortem human brain tissues for single-cell spatial analysis to study multiple sclerosis (MS) pathology. Chih Hung's research interest focuses on elucidating the mechanisms of neuroinflammation and neurodegeneration, specifically related to tau aggregation, aberrant receptor signaling, and autolysosomal dysfunctions in AD and MS.

Education and Experiences
B.Eng. (Biomedical Engineering), National University of Singapore (NUS), Singapore (2010-2014)
B.B.A. (Operation Management), National University of Singapore (NUS), Singapore (2010-2014)
Ph.D. (Biomedical Engineering), Minor in Management of Technology, University of Minnesota (UMN), USA (2014-2019) 
Postdoctoral Associate (Neurology), Brigham and Women's Hospital/Harvard Medical School, USA (2019-2020)
Postdoctoral Associate (Neurology), Yale University, School of Medicine, USA (2020-2021)
Dean's Postdoctoral Fellow (Neuroscience), Nanyang Technological University (NTU), LKC Medicine, Singapore (2021-Present)

Honors and Awards
2024                BBA Rising Star in Biochemistry & Biophysics 
2024 (Mar)      Early-Career Scientist Research Excellence Award, NTU, Singapore
2023 (Nov)      Trainee Professional Development Award, Society for Neuroscience (SfN), USA

2023 (Mar)      1 of the 10 Young Scientists selected by the National Research Foundation as Singapore representatives,
                        72nd Lindau Nobel Laureate Meeting (Physiology or Medicine), Germany

2023 (Mar)      Travel Award, Keystone Symposia on Autophagy & Neurodegeneration, USA
2022-2023       Mistletoe Research Fellowship (Unfettered Research Grant), Momental Foundation, USA
2022 (Sep)      Silver Award - Tan Kah Kee Young Inventors National Competition (Open Category)
2022 (May)      Best Poster Award, 1st Singapore Structural Biology Symposium (SSBS), Singapore
2021–2024      Dean’s Postdoctoral Fellowship (Independent Research Grant), LKC Medicine, NTU, Singapore  
2020–2021      NUS Development Grant (Named Young NUS Fellow)
2020 (Jun)       Best Dissertation Award (Ph.D.), Honorable Mention, University-Wide Competition, University of Minnesota, USA
2020 (May)      BME Department Best Dissertation Award (Ph.D.), University of Minnesota, USA
2020 (Apr)       Featured for Mentor-Graduate Student Spotlight, Journal of Life Sciences
2019  (Oct)      Trainee Professional Development Award, Society for Neuroscience (SfN), USA
2018–2019      Doctoral Dissertation Fellowship, University of Minnesota, USA
2018 (Nov)      Travel Grant, Council of Graduate Students, University of Minnesota, USA
2018 (Aug)      Travel Grant for National Meeting, Division of Medicinal Chemistry, American Chemical Society (ACS), USA
2018 (Feb)      Travel Award for Annual Meeting, Biophysical Society (BPS), USA

2017 (Apr)       Travel Award for Annual Meeting, American Society for Biochemistry and Molecular Biology (ASBMB), USA 
2017 (Jan)       Travel Fellowship, Invitation to the Global Young Scientists Summit, Singapore
2015 (Apr)       Culture Corps Award, ISSS, University of Minnesota, USA
2014 (Apr)       Best Presentation Award (Senior Thesis), 1st Prize, Biomedical Engineering Showcase, NUS, Singapore
2013 (Jan)       Award for Study Abroad Exchange Scholarship to University of California, San Diego (UCSD), NUS, Singapore
2012 (May)      Best Poster Award, Biomedical Engineering Society (Singapore) 6th Scientific Meeting, Singapore

Link to Publication List for Chih Hung Lo
1.  Lo CH, Zeng J, Perez-Aguilar JM, Baizabal-Aguirre VM. Peptide-based therapeutics with anti-inflammatory properties.
Singapore Provisional Patent Application No. 10202400831U.
2.  Sachs JN & Lo CH. Methods to identify modulator of tau protein structure. US Patent No. 11/726,081.

3.  Wood DK, Sachs JN, Vunnam N, Lo CH. Non-fibrillar hemoglobin oligomers and methods to identify modulators of hemoglobin S polymerization. US Patent Application No. 17/953,981.
4.  Tan JKS, Song SW, Goh AJY, Lo CH, Zeng J. Palm sticker as a personal protection equipment and as a surface swab.
US Provisional Patent Application No. 63/176,444.

1. Young Investigator Research Grant, National Medical Research Council, Singapore (PI: Lo)            
Project Title: Therapeutic and biomarker discovery for lysosomal acidification dysfunction in Alzheimer’s disease 

Timeline: 2023 – 2025 (In Progress)
2. Mistletoe Research Fellowship, Momental Foundation, USA (PI: Lo)      
Project Title: Unfettered research grant supporting the development of lysosome-acidifying nanoparticles targeting metabolic and neurodegenerative diseases
Timeline: 2022 – 2023 (Completed)
3. Dean’s Postdoctoral Fellowship, LKC School of Medicine,  Nanyang Technological University, Singapore (PI: Lo)           Project Title: Role of aberrant TNFR1 signaling in Alzheimer’s disease

Timeline: 2021 – 2024 (Completed)

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