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Peer-Reviewed Publications

Submitted and Published Papers

Team Publications (^Equal contribution / *Corresponding author)

17.  Lo CH^, Ren MLoi GWZ, Saipuljumri EN, Indajang J, Lim KL, Zeng J^* (2024) Lysosome-acidifying nanoparticles rescue A30P α-synuclein induced neuronal death in cellular and Drosophila models of Parkinson’s disease. Published in BioRxiv. Link 

16. Asimakidou E, Tan JKS, Zeng J*, Lo CH* (2024) Blood-brain barrier-targeting nanoparticles: biomaterial properties and biomedical applications in translational neuroscience. Pharmaceuticals, 17(5): 612. Link

15.  Lo CH* (2024) TNF receptors: structure-function relationships and therapeutic targeting strategies. BBA - Biomembranes, under review.

14.  Asimakidou E, Saipuljumri EN, Lo CHZeng J* (2024) Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration. Neural Regeneration Research, 10.4103/NRR.NRR-D-23-01770. Link

13.   Zeng J^, Loi GWZ, Saipuljumri EN, Silva-García O, Pérez-Aguilar JM, Romero Durán MA, Baizabal-Aguirre VM*,

Lo CH^* (2024) Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex. Proceedings of the National Academy of Sciences (PNAS), 121 (14) e2308132121. Link

(This study is featured in PNAS Showcase on Kudos: New therapeutic discovery helps fight inflammation Link)

12.  Lo CH^*, O'Connor LMLoi GWZ, Saipuljumri EN, Indajang J, Lopes KM, Shirihai OS, Grinstaff MW, Zeng J^* (2024) Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic condition. ACS Nano, Accepted. Published in BioRxiv. Link

11.   Asimakidou E, Reynolds R, Barron AM, Lo CH* (2024) Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer's disease. Neural Regeneration Research, 19(9): 1869. Link

10.  Lo CH^*, Zeng J^, Loi GWZ, Saipuljumri ENO'Connor LMIndajang J, Reynolds R, Barron AM (2023) Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer's disease. Published in BioRxiv. Link

9.   O’Connor LM, O’Connor BA, Zeng J, Lo CH* (2023) Data mining of microarray datasets in translational neuroscience. Brain Sciences, 13(9): 1318. Link

8.   Quick JD, Silva C, Wong JH, Lim KL, Reynolds R, Barron AM, Zeng J*, Lo CH* (2023) Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration. Journal of Neuroinflammation, 20: 185. Link

7.   Lo CH^*, Zeng J^* (2023) Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases. Translational Neurodegeneration, 12: 29. Link

6.   O’Connor LM, O’Connor BA, Lim SB, Zeng J, Lo CH* (2023) Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective. Journal of Pharmaceutical Analysis, In Press. Link

5.   Zeng J*, Acin-Perez R, Assali EA, Martin A, Brownstein AJ, Petcherski A, Fernández-del-Rio L, Xiao R, Lo CH, Shum M, Liesa-Roig M, Han X, Shirihai O*, Grinstaff MW* (2023). Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease. Nature Communications, 14(1): 2573. Link 

(This study is featured in Nature Reviews Gastroenterology & Hepatology Link)

4.  Lo CH^*, Zeng J^* (2023). Application of polymersomes in membrane protein study and drug discovery. Bioengineering & Translational Medicine,  8(1): e10350. Link 

3.  Tan JKS^*, Song SW^*, Zeng J^*, Lo CH^* (2022). Targeting fomite transmission of viruses: A novel hand-targeted auxiliary personal protective equipment. Bioengineering & Translational Medicine, e10411. Link

2.  Lo CH* (2022) Heterogeneous tau oligomer as molecular target for Alzheimer's disease and related tauopathies. Biophysica, 2(4): 440-451 Link

(*Corresponding author)

1.   Lo CH* (2021). Recent advances in cellular biosensor technology to investigate tau oligomerization. Bioengineering & Translational Medicine, 2021: e10231. Link

Chih Hung Lo (Publications during PhD and Postdoctoral work)

19.  Vunnam N^, Yang M^, Lo CH^, Paulson CN, Fiers WD, Huber EC, Been MJO, Ferguson DM, Sachs JN (2023). Zafirlukast is a promising scaffold for selectively inhibiting TNFR1 signaling. ACS Bio & Med Chem Au, 3(3): 270-282. Link (^Equal contribution)

18.  Vunnam N, Young MC, Liao EE, Lo CH, Huber EC, Been MJO, Thomas DD, Sachs JN (2023). Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering. Cancer Biology & Therapy, 24(1): Article 2176692. Link

17.  Pitt D, Lo CH, Gauthier SA, Hickman R, Longbrake E, Airas LM, Mao-Draayer, Riley YC, De Jager PL, Wesley S, Boster A, Topalli I, Bagnato F, Mansoor M, Stuve O, Kister I, Pelletier D, Stathopulous P, Dutta R, Lincoln M (2022). Towards a unified view of multiple sclerosis. Neurology Neuroimmunology &

Neuroinflammation,  9(6): e200025. Link 

16. Vunnam N, Hansen S, Williams DC, Been MJO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs, JN, Wood DK (2022) Fluorescence lifetime measurement of prefibrillar sickle hemoglobin oligomers as a platform for drug discovery in sickle cell disease. Biomacromolecules, 23(9): 3822-3830 Link

15.  Kandavalli S, Kandavalli S, Ruban R, Lo CH, Kumar R, Gupta M, Pruncu C (2021). A comprehensive review on ceramic used for dental materials: manufacturing techniques and microstructure. ECS Journal of Solid State Science and Technology, 11(5): 053005. Link

14. Zinger N, Ponath G, Sweeney E, Nguyen TD, Lo CH, Diaz I, Dimov A, Teng L, Zexter L, Comunale J, Wang Y, Pitt D, Gauthier SA (2022). Dimethyl fumarate reduces inflammation in chronic active multiple sclerosis lesions. Neurology Neuroimmunology & Neuroinflammation, 9(2): e1138. Link

13.   Lo CH, Skarica M, Mansoor M, Bhandarkar S, Toro S, Pitt D (2021). Astrocyte heterogeneity in multiple sclerosis: current understanding and technical challenges. Frontiers in Cellular Neuroscience, 15: Article 726479. Link

12.   Rahman A, Lo CH, Ramic A, Jahan Y (2021). Dementia in media coverage: a comparative analysis of two online newspapers across time. International Journal of Environmental Research and Public Health, 18(19), 10539. Link

11.   Braun AR, Liao EE, Horvath M, Kalra P, Acosta K, Young MC, Kochen NN, Lo CH, Brown R, Evans MD, Pomerantz WCK, Rhoades E, Luk K, Cornea RL, Thomas DD, Sachs JN (2021). Potent inhibitors of toxic alpha-synuclein oligomers identified via cellular time-resolved FRET biosensor. npj Parkinson’s Disease, 7(1): 1-17. Link

10.   Klionsky DJ, …, Lo CH, et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1): 1-382. Link
9.    Lo CH, Schaaf TM, Thomas DD, Sachs JN (2021). Fluorescence based TNFR1 biosensor for monitoring of receptor structural and conformational dynamics and discovery of small molecule modulators. In The TNF Superfamily. Methods in Molecular Biology, 2248: 121-137. Link

8.    Lo CH*, Sachs JN* (2020). The role of wild-type tau in Alzheimer’s disease and related tauopathies. Journal of Life Sciences, 2(4): 1-17. Link

(*Corresponding author)

7.    Rahman A, Lo CH, Ramic A, Jahan Y (2020). Home-based care for people with Alzheimer’s disease and related dementias (ADRD) during COVID-19 pandemic: from challenges to solutions. International Journal of Environmental Research and Public Health, 17(24): 9303. Link

6.    Lo CH, Pandey NK, Lim CKW, Ding Z, Tao M, Langen R, Thomas DD, Sachs JN (2020). Discovery of novel small-molecule inhibitors of huntingtin axon 1 aggregation by FRET-based high-throughput screening in living cells. ACS Chemical Neuroscience, 11(15): 2286-2295. Link

5.    Lo CH, Huber EC, Sachs JN (2020). Conformational states of TNFR1 as a molecular switch for receptor function. Protein Science 29(6): 1401-1415. Link
4.    Lo CH, Lim CKW, Ding Z, Wickramasinghe SP, Braun AR, Ashe KH, Rhoades E, Thomas DD, Sachs JN (2019). Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 15(11): 1489-1502. Link 

Spotlight in Journal of Life Sciences.

3.    Lo CH, Schaaf TM, Grant BD, Lim CKW, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN (2019). Noncompetitive inhibitors of TNFR1 probe conformational activation states. Science Signaling 12(592): eaav5637. Link
Featured in European Biotechnology Magazine.

2.    Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN (2017). Soluble extracellular domain of death receptor 5 inhibits TRAIL-induced apoptosis by disrupting receptor-receptor interactions. Journal of Molecular Biology 429(19): 2943-2953. Link
1.    Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN (2017). An innovative high-throughput screening approach for discovery of small molecules that inhibit TNF Receptors. SLAS Discovery 22(8): 950-961. Link

Jialiu Zeng (Publications during PhD and Postdoctoral work)

14.   Xiao R^, Zeng J^, Bressler E, Lu W, Grinstaff MW (2021). Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages. Nature Communications, 13(1): 4661. Link

(^Equal contribution) 

13.   Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin W, Karmaus PWF, Martinez J, Li Q, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB (2021). IRGM1 links mitochondrial quality control to autoimmunity. Nature Immunology, 22: 312-321. Link

12.   Klionsky DJ, …, Zeng J, et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1): 1-382. Link

11.    Zeng J*, Shirihai OS, Grinstaff MW* (2020). Modulating lysosomal pH: a molecular and nanoscale materials design perspective. Journal of Life Sciences, 2(4): 25-37. Link

(*Corresponding author)

10.   Ang EH, Zeng J, Subramanian GS, Chellappan V, Sudhaharan T, Padmanabhan P, Gulyás B, Selvan ST (2020). Silica-coated Mn-doped ZnS nanocrystals for cancer theranostics. ACS Applied Nano Materials, 3(3): 3088–30967. Link

9.    Zeng J*, Martin A, Han X, Shirihai OS, Grinstaff MW* (2019). Biodegradable PLGA nanoparticles restore lysosomal acidity and protect neural PC-12 cells against mitochondrial toxicity. Industrial & Engineering Chemistry Research, 58(31): 13910-13917. Link

(*Corresponding author)

8.    Zeng J, Shirihai OS, Grinstaff MW. (2019). Degradable nanoparticles restore lysosomal pH and autophagic flux in lipotoxic pancreatic beta cells. Advanced Healthcare Materials, 8(12): 1801511. Spotlight in Journal of Life Sciences. Link

7.    Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS (2019). Nanoparticle‐mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity. The FASEB Journal, 33(3): 4154-4165. Link

6.    Xiao R, Zeng J, Grinstaff MW (2018). Biologically active branched polysaccharide mimetics: synthesis via ring-opening polymerization of a maltose-based β-lactam. ACS Macro Letters, 7(7): 772-777. Link

5.    Xiao R, Dane EL, Zeng J, McKnight CJ, Grinstaff MW (2017). Synthesis of altrose poly-amido-saccharides with β-N-(1→2)-D-amide linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level. Journal of the American Chemical Society, 139(40): 14217-14223. Link 

4.    Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai OS, Grinstaff MW, Colson YL (2016). Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials, 102: 175-186. Link

3.    KM Trudeau, Colby AH, Zeng J, Las G, Feng JH, Grinstaff MW, Shirihai OS (2016). Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. Journal of Cell Biology, 214(1): 25-34. Link

2.    Dinda S, Kakran M, Zeng J, Sudhaharan T, Ahmed S, Das D, Selvan ST (2016). Grafting of ZnS: Mn-doped nanocrystals and an anticancer drug onto graphene oxide for delivery and cell labeling. ChemPlusChem, 15, 81(1):100. Link

1.    Li Y, Oo ZY, Chang SY, Huang P, Eng KG, Zeng J, Kaestli AJ, Gopalan B, Kandasamy K, Tasnim F, Zink D (2013). An in vitro method for the prediction of renal proximal tubular toxicity in humans. Toxicology Research, 2(5): 352-365. Link

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